Analytical Data
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Gene name
Serpinh1
- Application
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Alternative Names
Serpinh1；CBP1；CBP2；HSP47；Serpin H1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P50454
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Expression Region
19-418aa
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AA Sequence
AEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL
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Molecular Weight
50.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Serpinh1, also known as serine peptidase inhibitor clade H member 1, is a critical molecular chaperone primarily involved in the folding and stabilization of collagen, a key structural protein in various tissues. The research background of Serpinh1 is rooted in its role in cellular homeostasis, particularly in connective tissues, where it facilitates proper collagen synthesis and assembly. Abnormalities or mutations in the Serpinh1 gene can lead to a spectrum of disorders, including osteogenesis imperfecta and other connective tissue diseases. Given its vital function in collagen metabolism, Serpinh1 has gained attention in studies focused on understanding the molecular mechanisms underlying these diseases. Furthermore, the protein is also implicated in tumor biology, inflammation, and fibrotic diseases, making it a potential therapeutic target. Recent advancements in recombinant protein technology have enabled the production and characterization of Serpinh1 for both basic science and clinical applications. By generating recombinant forms of Serpinh1, researchers aim to investigate its biochemical properties, interaction with collagen, and potential roles in disease pathology. This research not only contributes to the understanding of connective tissue homeostasis but also holds promise for the development of new therapeutic interventions for related disorders. Overall, the study of Serpinh1 represents a convergence of molecular biology, genetics, and translational medicine, highlighting its importance in both health and disease.
