Analytical Data
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Gene name
VEGFR1
- Application
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Alternative Names
VEGFR1；FLT；FRT；VEGFR1；Vascular endothelial growth factor receptor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P17948
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Expression Region
25-688aa
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AA Sequence
SGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERL SITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAI YIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPL DTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHR QTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNK RASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT SVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGL PATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIV NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHN HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVV ADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLK LSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIM NVSLQDSGTYACRARNVYTGEEILQKKEITIRGEHCNKKAVFSRISKFKS TRNDCTTQSNVKH
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) is a key player in the regulation of angiogenesis, the process through which new blood vessels form from pre-existing ones. It is primarily involved in mediating the effects of vascular endothelial growth factors (VEGFs), which are crucial for embryonic development, wound healing, and pathological processes such as cancer progression. VEGFR1 is known to have a high affinity for VEGF, but its precise role in signaling pathways remains complex, as it can both promote and inhibit downstream effects depending on the context and availability of ligands. Research has increasingly focused on recombinant VEGFR1 proteins to elucidate its biochemical properties, interactions with ligands, and the mechanisms through which it influences endothelial cell behavior. These studies aim to provide insights into the therapeutic potential of targeting VEGFR1 in diseases characterized by abnormal angiogenesis, such as cancer and diabetic retinopathy. By investigating the structure and function of recombinant VEGFR1, scientists hope to develop novel strategies for inhibiting tumor growth and metastasis, offering new avenues for effective treatment options. This research is vital for understanding the dual role of VEGFR1 and its potential as a biomarker or therapeutic target in various angiogenesis-related disorders.
