Analytical Data
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基因名
SEC16A
- Application
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别名
SEC16A；KIAA0310；SEC16；SEC16L；Protein transport Protein Sec16A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15027
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表达区间
1943-2154aa
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氨基酸序列
AYLPDDKNKSIVWDEKKNQWVNLNEPEEEKKAPPPPPTSMPKTVQAAPPALPGPPGAPVNMYSRRAAGTRARYVDVLNPSGTQRSEPALAPADFVAPLAPLPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKLSRCSSMSSLSREVSQHFNQAPGDLPAAGGPPSGAMPFYNPAQLAQACATSGSSRLGRIGQRKHLVLN
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分子量
26.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEC16A is a crucial protein implicated in the regulation of secretory processes within the endoplasmic reticulum (ER) and the Golgi apparatus. It plays a significant role in the organization of ER exit sites, which are essential for the efficient transport of proteins to their intended destinations. Mutations or dysregulation of SEC16A have been linked to various developmental disorders and diseases, including intellectual disabilities and congenital disorders of glycosylation. Researchers have been investigating the structure and function of SEC16A to better understand its role in cellular trafficking and protein secretion. Recent studies using advanced imaging techniques and molecular biology methods have provided insights into the dynamic nature of SEC16A interactions with other proteins at the ER membrane, revealing its critical function in maintaining cellular homeostasis. Understanding SEC16A's mechanistic pathways not only sheds light on fundamental cellular processes but also presents potential therapeutic avenues for conditions associated with its malfunction. This ongoing research has significant implications for the fields of cell biology and medicine, particularly in developing targeted strategies for managing SEC16A-related disorders.
