Analytical Data
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Gene name
RSPO3
- Application
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Alternative Names
RSPO3；PWTSR；THSD2；R-spondin-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXY4-1
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Expression Region
1-146aa
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AA Sequence
MHLRLISWLF IILNFMEYIG SQNASRGRRQ RRMHPNVSQG CQGGCATCSD YNGCLSCKPR LFFALERIGM KQIGVCLSSC PSGYYGTRYP DINKCTKCKA DCDTCFNKNF CTKCKSGFYL HLGKCLDNCP EGLEANNHTM ECVSIV
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RSPO3 (R-spondin 3) is a member of the R-spondin family, which plays a crucial role in the regulation of Wnt signaling pathways, fundamental for various biological processes, including cell proliferation, differentiation, and stem cell maintenance. Abnormal regulation of Wnt signaling is associated with several diseases, including cancer and developmental disorders. RSPO3 specifically acts as a potent enhancer of the Wnt pathway by stabilizing the interaction between Wnt ligands and their receptors. Research has indicated that RSPO3 is involved in important physiological processes, such as organ development and tissue regeneration, making it a valuable target for therapeutic strategies. Moreover, its expression patterns in various tissues contribute to the understanding of its functional implications in developmental biology and pathology. Current studies are focused on elucidating the molecular mechanisms by which RSPO3 influences Wnt signaling and identifying its potential roles in diseases, particularly in the context of tumorigenesis and stem cell biology. Understanding RSPO3's function could pave the way for innovative treatments and interventions aimed at modulating Wnt signaling pathways in various clinical settings.
