Analytical Data
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Gene name
PRRX1
- Application
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Alternative Names
AGOTC; Homeobox protein PHOX1; Paired mesoderm homeo box 1; Paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; Paired mesoderm homeobox protein 1; Paired related homeobox 1; Paired related homeobox protein 1; Paired-related homeobox protein 1; PHOX 1; PHOX1 1. 2; PHOX1; PMX 1; PMX1; PRRX 1; Prrx1; PRRX1_HUMAN; PRX 1 ; PRX-1; PRX1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54821
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Expression Region
1-245 aa
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AA Sequence
MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADENVGEA GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ VPTVN
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Molecular Weight
27.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PRRX1, or Paired Related Homeobox 1, is a member of the homeobox gene family, which plays a pivotal role in various developmental processes and has been implicated in multiple cellular functions, including migration, differentiation, and proliferation. Recent studies have highlighted its potential involvement in cancer progression, particularly in facilitating epithelial-mesenchymal transition (EMT), a critical event that enhances metastasis in solid tumors. The dual roles of PRRX1 as both a tumor suppressor and promoter, depending on the cancer context, underscore its complexity and importance in tumor biology. Research has demonstrated that PRRX1 can regulate key signaling pathways, including the transforming growth factor-beta (TGF-β) pathway, further linking it to cancer metastasis and stemness characteristics in tumors. Given its influential roles, characterizing PRRX1 through recombinant protein studies can provide insights into its functional mechanisms and interactions with other molecular players in cancer and developmental biology. Understanding PRRX1’s structure and function may also pave the way for novel therapeutic strategies targeting cancer metastasis and improving outcomes in patients with aggressive malignancies. The generation of PRRX1 recombinant proteins enables detailed exploration of its biochemical properties, interactions, and regulatory networks, making it a focal point for ongoing research in the fields of molecular biology and oncology.
