Analytical Data
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基因名
GADD45B
- Application
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别名
GADD45B；MYD118；Growth arrest and DNA damage-inducible Protein GADD45 beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75293
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表达区间
1-160aa
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氨基酸序列
MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GADD45B (Growth Arrest and DNA Damage-inducible protein 45 beta) is part of the GADD45 family, which plays a crucial role in cellular stress responses, DNA repair, and apoptosis. Its involvement in various physiological processes, including cell cycle regulation and immune responses, has drawn considerable research interest. Studies have shown that GADD45B is upregulated in response to genotoxic stress and is implicated in tumorigenesis, making it a potential biomarker and therapeutic target in cancer research. The recombinant protein of GADD45B has been produced to study its structure-function relationships and interactions with other cellular proteins. Investigating the biochemical properties and signaling pathways associated with GADD45B can shed light on its role in maintaining genomic stability and its potential implications in cancer therapy. Understanding these mechanisms may offer insights into designing novel therapeutic strategies that leverage GADD45B's functions in tumor suppression and cell survival in the face of DNA damage.
