Analytical Data
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基因名
OTX2
- Application
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别名
OTX2；Homeobox Protein OTX2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32243
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表达区间
1-297aa
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氨基酸序列
MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL
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分子量
48.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OTX2 (Orthodenticle Homeobox 2) is a critical transcription factor involved in various developmental processes, particularly in the regulation of neurogenesis and eye development. Mutations or dysregulation of OTX2 have been linked to several developmental disorders, including retinal degeneration and congenital eye malformations. Given its pivotal role in embryonic development and potential implications in regenerative medicine, there has been increasing interest in the characterization of OTX2 recombinant proteins. This research aims to produce OTX2 in a recombinant form to facilitate functional studies that can elucidate its molecular mechanisms and interactions with other proteins. Understanding the structure and function of OTX2 through recombinant protein studies can provide insights into its role in cellular processes, as well as its potential as a therapeutic target. By employing techniques such as molecular cloning, protein expression, and purification, researchers strive to generate high-quality OTX2 protein, which can be utilized in various assays, including binding studies and functional assays in cell cultures. This research not only contributes to the fundamental understanding of OTX2 but also paves the way for potential applications in treating conditions associated with OTX2 dysfunction.
