Analytical Data
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基因名
LHCGR
- Application
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别名
LHCGR；LCGR；LGR2；LHRHR；Lutropin-choriogonadotropic hormone receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22888
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表达区间
27-363aa
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氨基酸序列
EALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLR
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分子量
41.6 Da
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LHCGR, or Luteinizing Hormone/Choriogonadotropin Receptor, plays a crucial role in reproductive physiology by mediating the actions of luteinizing hormone (LH) and human chorionic gonadotropin (hCG). This G protein-coupled receptor is primarily expressed in ovarian and testicular tissues, where it is essential for regulating gonadal function, including the maturation of oocytes and testosterone production. Dysregulation or mutations in the LHCGR gene can lead to various reproductive disorders such as hypogonadism, ovarian hyperstimulation syndrome, and certain cases of infertility. The study of LHCGR recombinant proteins is significant for understanding these disorders and developing potential therapeutic interventions. Recombinant LHCGR proteins can be used to investigate receptor functionality, signaling pathways, and interactions with ligands, thereby providing insights into receptor pharmacology. Additionally, such studies can aid in the design of novel drugs targeting this receptor, which could enhance fertility treatments or address conditions arising from receptor malfunctions. The ongoing research surrounding LHCGR and its recombinant proteins is vital not only for basic biological understanding but also for advancing reproductive health and addressing related clinical challenges.
