Analytical Data
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Gene name
LHCGR
- Application
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Alternative Names
LHCGR；LCGR；LGR2；LHRHR；Lutropin-choriogonadotropic hormone receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P22888
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Expression Region
27-363aa
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AA Sequence
EALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLR
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Molecular Weight
41.6 Da
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LHCGR, or Luteinizing Hormone/Choriogonadotropin Receptor, plays a crucial role in reproductive physiology by mediating the actions of luteinizing hormone (LH) and human chorionic gonadotropin (hCG). This G protein-coupled receptor is primarily expressed in ovarian and testicular tissues, where it is essential for regulating gonadal function, including the maturation of oocytes and testosterone production. Dysregulation or mutations in the LHCGR gene can lead to various reproductive disorders such as hypogonadism, ovarian hyperstimulation syndrome, and certain cases of infertility. The study of LHCGR recombinant proteins is significant for understanding these disorders and developing potential therapeutic interventions. Recombinant LHCGR proteins can be used to investigate receptor functionality, signaling pathways, and interactions with ligands, thereby providing insights into receptor pharmacology. Additionally, such studies can aid in the design of novel drugs targeting this receptor, which could enhance fertility treatments or address conditions arising from receptor malfunctions. The ongoing research surrounding LHCGR and its recombinant proteins is vital not only for basic biological understanding but also for advancing reproductive health and addressing related clinical challenges.
