Analytical Data
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基因名
SCARB1
- Application
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别名
SCARB1；CD36L1；CLA1；Scavenger receptor class B member 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WTV0
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表达区间
33-443aa
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氨基酸序列
PSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGE KPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESD YIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWG YKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIH LVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRS MKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVS TCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPM NCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYT QLVLMPKVMHY
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分子量
73 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCARB1, or scavenger receptor class B type I, is a key membrane protein primarily involved in high-density lipoprotein (HDL) metabolism and cholesterol homeostasis. As a receptor for HDL, SCARB1 plays a crucial role in mediating the selective uptake of cholesterol from HDL into cells. This function is especially important in hepatocytes and steroidogenic tissues, where cholesterol is vital for the synthesis of bile acids, steroid hormones, and cellular membranes. Dysregulation of SCARB1 has been linked to various metabolic disorders, including cardiovascular diseases and type 2 diabetes. Researchers have increasingly focused on SCARB1 as a potential therapeutic target for these conditions. The study of SCARB1 recombinant proteins allows for a deeper understanding of its structural and functional properties, facilitating the investigation of its role in lipid metabolism and its interactions with ligands such as HDL. Furthermore, recombinant SCARB1 can serve as a valuable tool in drug discovery and development, enabling the screening of small molecules that may modulate its activity. Overall, the exploration of SCARB1 and its recombinant variants holds promise for uncovering new insights into lipid metabolism and developing novel therapeutic strategies for cardiovascular and metabolic diseases.
