Analytical Data
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Gene name
DOK5
- Application
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Alternative Names
DOK5；C20orf180；Docking Protein 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P104
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Expression Region
1-198aa
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AA Sequence
MECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH
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Molecular Weight
38.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DOK5 (Downstream of Kinase 5) is a member of the DOK family of scaffold proteins, which play crucial roles in cellular signaling pathways. The study of DOK5 is particularly significant due to its involvement in various cellular processes, including proliferation, differentiation, and survival, especially in the context of cancer biology. Research has identified DOK5 as a key mediator in receptor tyrosine kinase signaling pathways and highlighted its potential role in oncogenesis. Elevated expression levels of DOK5 have been observed in several cancer types, suggesting a link between abnormal DOK5 activity and tumor progression. Additionally, DOK5 has been implicated in modulating immune responses, making it a potential target for therapeutic interventions. Understanding the molecular mechanisms underlying DOK5 function and its interactions with other signaling molecules can provide insight into its role in disease states. Consequently, the development of recombinant DOK5 proteins is essential for probing its structure-function relationships and uncovering the complex regulatory networks it participates in. Studies utilizing recombinant DOK5 aim to elucidate its biological roles and support the identification of novel therapeutic strategies targeting DOK5-related pathways in cancer and other diseases.
