Analytical Data
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基因名
DOK5
- Application
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别名
DOK5；C20orf180；Docking Protein 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P104
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表达区间
1-198aa
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氨基酸序列
MECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH
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分子量
38.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DOK5 (Downstream of Kinase 5) is a member of the DOK family of scaffold proteins, which play crucial roles in cellular signaling pathways. The study of DOK5 is particularly significant due to its involvement in various cellular processes, including proliferation, differentiation, and survival, especially in the context of cancer biology. Research has identified DOK5 as a key mediator in receptor tyrosine kinase signaling pathways and highlighted its potential role in oncogenesis. Elevated expression levels of DOK5 have been observed in several cancer types, suggesting a link between abnormal DOK5 activity and tumor progression. Additionally, DOK5 has been implicated in modulating immune responses, making it a potential target for therapeutic interventions. Understanding the molecular mechanisms underlying DOK5 function and its interactions with other signaling molecules can provide insight into its role in disease states. Consequently, the development of recombinant DOK5 proteins is essential for probing its structure-function relationships and uncovering the complex regulatory networks it participates in. Studies utilizing recombinant DOK5 aim to elucidate its biological roles and support the identification of novel therapeutic strategies targeting DOK5-related pathways in cancer and other diseases.
