Analytical Data
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Gene name
SERPINA6
- Application
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Alternative Names
SERPINA6；CBG；Corticosteroid-binding globulin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08185
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Expression Region
23-405aa
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AA Sequence
MDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
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Molecular Weight
69.6kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SERPINA6, also known as corticosteroid-binding globulin (CBG), is a glycoprotein that plays a crucial role in the transport and regulation of glucocorticoids in the bloodstream. Its primary function is to bind cortisol and corticosterone, thereby modulating their availability and activity at the receptor level in tissues. The importance of SERPINA6 in various physiological and pathological processes, including stress response, inflammation, and metabolic disorders, has sparked significant interest in its structure and function. Alterations in CBG levels are associated with various diseases, such as chronic stress, obesity, and depression, making it a potential biomarker for these conditions. The study of recombinant SERPINA6 protein allows researchers to investigate its functional properties, interactions with glucocorticoids, and influence on signaling pathways more extensively. Furthermore, recombinant protein production facilitates the development of therapeutic agents that can potentially target conditions related to glucocorticoid dysregulation. Understanding the biology of SERPINA6 at a molecular level not only contributes to our knowledge of endocrine regulation but also opens avenues for novel therapeutic interventions in stress-related and metabolic disorders.
