Analytical Data
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Gene name
SERPINA10
- Application
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Alternative Names
SERPINA10；ZPI；Protein Z-dependent protease inhibitor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UK55
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Expression Region
22-444aa
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AA Sequence
LAPSPQSPE TPAPQNQTSR VVQAPKEEEE DEQEASEEKA SEEEKAWLMA SRQQLAKETS NFGFSLLRKI SMRHDGNMVF SPFGMSLAMT GLMLGATGPT ETQIKRGLHL QALKPTKPGL LPSLFKGLRE TLSRNLELGL TQGSFAFIHK DFDVKETFFN LSKRYFDTEC VPMNFRNASQ AKRLMNHYIN KETRGKIPKL FDEINPETKL ILVDYILFKG KWLTPFDPVF TEVDTFHLDK YKTIKVPMMY GAGKFASTFD KNFRCHVLKL PYQGNATMLV VLMEKMGDHL ALEDYLTTDL VETWLRNMKT RNMEVFFPKF KLDQKYEMHE LLRQMGIRRI FSPFADLSEL SATGRNLQVS RVLQRTVIEV DERGTEAVAG ILSEITAYSM PPVIKVDRPF HFMIYEETSG MLLFLGRVVN PTLL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SERPINA10, also known as protein Z-dependent protease inhibitor (ZPI), is a serine protease inhibitor that plays a significant role in the regulation of coagulation and inflammation processes. It is primarily expressed in the liver and circulates in the bloodstream, where it functions to inhibit factors that can lead to excessive clotting and inflammation. Research into SERPINA10 has gained traction due to its potential implications in various pathological conditions, including thrombosis, cardiovascular diseases, and certain cancers. The recombinant form of SERPINA10 is particularly valuable for both therapeutic and diagnostic applications, as it enables a deeper understanding of its biological functions and mechanisms of action. Advances in recombinant protein technology have made it feasible to produce this protein in controlled environments, facilitating rigorous studies. Understanding the structure-function relationships of SERPINA10 can provide insights into the modulation of its inhibitory activity, offering potential strategies for the development of novel anticoagulant therapies. Moreover, the role of SERPINA10 in the immune response highlights its potential as a biomarker for disease progression and treatment efficacy. Ongoing investigations are focused on elucidating the precise mechanisms by which SERPINA10 exerts its effects in biological systems, thereby paving the way for new interventions in diseases characterized by dysregulated coagulation and inflammation.
