Analytical Data
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基因名
RNASE6
- Application
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别名
RNASE6；RNS6；Ribonuclease K6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q93091
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表达区间
24-150aa
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氨基酸序列
WPKRLTKAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLHDSFQNVAAVCDLLSIVCKNRRHNCHQSSKPVNMTDCRLTSGKYPQCRYSAAAQYKFFIVACDPPQKSDPPYKLVPVHLDSIL
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分子量
19.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNASE6, a member of the ribonuclease A superfamily, is an endonuclease known for its potential roles in various biological processes, including innate immunity and inflammation. The protein has garnered attention due to its involvement in RNA processing and its capacity to degrade double-stranded RNA, which is crucial for defending against viral infections. Increased expression of RNASE6 has been observed in various inflammatory conditions, suggesting it may serve as a biomarker for disease and a target for therapeutic intervention. Additionally, studies have indicated that RNASE6 might modulate immune responses by influencing macrophage activity and cytokine production. Given its multifaceted roles, the recombination and characterization of RNASE6 protein are essential for understanding its structure-function relationship and therapeutic potential. The exploration of RNASE6 in recombinant form allows for detailed biochemical assays, structural studies, and functional assays, which can elucidate its mechanisms of action in immune responses and disease pathology. Moreover, recombinant RNASE6 could facilitate the development of novel therapeutic strategies for diseases driven by dysregulated inflammation or viral infections, making it a significant focus of current biomedical research.
