Analytical Data
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基因名
CSNK1E
- Application
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别名
CSNK1E；Casein kinase I isoform epsilon
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49674
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表达区间
1-416aa
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氨基酸序列
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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分子量
49.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSNK1E, or Casein Kinase 1 Epsilon, is a member of the Casein Kinase 1 (CK1) family, which plays a crucial role in various cellular processes, including cell cycle regulation, circadian rhythms, and signal transduction pathways. Research on CSNK1E has garnered attention due to its implications in several diseases, including cancer and neurodegenerative disorders. Its involvement in the Wnt signaling pathway and the regulation of key proteins like β-catenin highlight its significance in cellular growth and differentiation. Recombinant CSNK1E protein has become a valuable tool for scientists to investigate its enzymatic activity, substrate specificity, and interaction with other cellular components. Understanding CSNK1E's structure and function through recombinant protein studies may aid in the development of targeted therapies and provide insights into its role in disease mechanisms. As a result, the study of CSNK1E recombinant proteins not only enhances our basic knowledge of cellular signaling but also holds promise for therapeutic advancements in various pathologies linked to CK1 family kinases.
