Analytical Data
-
基因名
PRKAR1A
- Application
-
别名
ACRDYS1; ADOHR; cAMP dependent protein kinase regulatory subunit alpha 1; cAMP dependent protein kinase regulatory subunit RIalpha; cAMP dependent protein kinase type I alpha regulatory chain; cAMP dependent protein kinase type I alpha regulatory subunit; cAMP-dependent protein kinase type I-alpha regulatory subunit; CAR; Carney complex type 1; CNC 1; CNC; CNC1; DKFZp779L0468; KAP0_HUMAN; MGC17251; PKA RIA ; PKR 1; PKR1; PPNAD 1; PPNAD1; PRKAR 1; PRKAR1; PRKAR1A; PRKAR1A/RARA FUSION GENE; Protein kinase A type 1a regulatory subunit; Protein kinase cAMP dependent regulatory type I alpha; PTC2 CHIMERIC ONCOGENE; INCLUDED; Tissue specific extinguisher 1; Tissue-specific extinguisher 1; TSE 1; TSE1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P10644
-
表达区间
1-381 aa
-
氨基酸序列
MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFSVSFIA GETVIQQGDE GDNFYVIDQG ETDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
-
分子量
42.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PRKAR1A is a critical gene that encodes the regulatory subunit type 1-alpha of protein kinase A (PKA), which plays a pivotal role in various cellular processes, including metabolism, cell proliferation, and differentiation. Mutations in the PRKAR1A gene have been linked to various human diseases, particularly those associated with dysregulated growth signaling, such as Carney complex, a familial syndrome characterized by neoplasms, lentigines, and endocrine disorders. The study of PRKAR1A recombinant proteins has gained considerable attention as researchers aim to understand its functional implications in cellular signaling pathways, particularly in tumorigenesis and endocrine function. Successful recombinant expression of PRKAR1A allows for detailed investigation of its structural properties and interactions with other proteins involved in cAMP signaling. These studies are essential for elucidating the molecular mechanisms by which PRKAR1A mutations contribute to oncogenesis and other pathological conditions. Additionally, the development of PRKAR1A-based therapeutic strategies holds promise for innovative treatments for related disorders. Understanding this protein's role and functionality could offer pivotal insights for targeted therapies and personalized medicine approaches in handling diseases associated with PRKAR1A dysregulation. As researchers continue to delve into the complexities of PKA signaling pathways, the significance of PRKAR1A in both normal physiology and disease states remains a focal point of biomedical research.
