Analytical Data
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Gene name
ATPAF2
- Application
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Alternative Names
ATPAF2；ATP12；ATP synthase mitochondrial F1 complex assembly factor 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N5M1
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Expression Region
41-289aa
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AA Sequence
APPTERKRFYQNVSITQGEGGFEINLDHRKLKTPQAKLFTVPSEALAIAVATEWDSQQDTIKYYTMHLTTLCNTSLDNPTQRNKDQLIRAAVKFLDTDTICYRVEEPETLVELQRNEWDPIIEWAEKRYGVEISSSTSIMGPSIPAKTREVLVSHLASYNTWALQGIEFVAAQLKSMVLTLGLIDLRLTVEQAVLLSRLEEEYQIQKWGNIEWAHDYELQELRARTAAGTLFIHLCSESTTVKHKLLKE
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Molecular Weight
32.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATPAF2, or ATP synthase assembly factor 2, is a crucial protein involved in the assembly and function of ATP synthase, a key enzyme complex in cellular respiration that synthesizes adenosine triphosphate (ATP). Research on ATPAF2 has gained momentum due to its significant role in mitochondrial biogenesis and energy production. Mutations or dysregulation of ATPAF2 have been implicated in various mitochondrial disorders, which can lead to a range of metabolic and degenerative diseases. Understanding the molecular mechanisms by which ATPAF2 facilitates ATP synthase assembly is essential for developing potential therapeutic strategies for these conditions. Recent studies have highlighted the protein's interaction with nuclear and mitochondrial DNA, suggesting its involvement in the coordination of gene expression necessary for mitochondrial function. Additionally, investigating ATPAF2's role in stress responses and its potential regulatory pathways could provide insights into how cells adapt to metabolic demands. Given the increasing prevalence of mitochondrial diseases and their profound impact on human health, research into ATPAF2 is critical for unraveling the complexities of mitochondrial dynamics and for the discovery of novel interventions to enhance mitochondrial function.
