Analytical Data
-
基因名
PPP2R1B
- Application
-
别名
2AAB_HUMAN; beta isoform of regulatory subunit A; protein phosphatase 2; PP2A A beta; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta; PP2A; subunit A; PR65 beta isoform; PP2A; subunit A; R1 beta isoform; PPP2R1B; PPP4R1; PR65B; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); beta isoform; protein phosphatase 2 (formerly 2A); regulatory subunit A; beta isoform; Protein phosphatase 2; regulatory subunit A; beta; Protein phosphatase 2; structural/regulatory subunit A; beta; protein phosphatase 2; structural/regulatory subunit A; beta isoform; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A; beta isoform; serine/threonine protein phosphatase 2A; 65 kDa regulatory subunit A; beta isoform; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P30154
-
表达区间
2-601 aa
-
氨基酸序列
AGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL A
-
分子量
66.2 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP2R1B, a gene encoding the B regulatory subunit of protein phosphatase 2A (PP2A), plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Mutations and alterations in PPP2R1B have been implicated in the development of several cancers, making it a significant focus of cancer research. Understanding the function and regulation of PPP2R1B can provide insights into tumorigenesis and the potential for therapeutic interventions. Research has shown that the deregulation of PP2A activity, often due to aberrations in its regulatory subunits like PPP2R1B, contributes to oncogenic signaling pathways, highlighting the importance of this protein in maintaining cellular homeostasis. As a result, studying recombinant PPP2R1B proteins can aid in elucidating the molecular mechanisms underlying its role in cancer and help identify potential biomarkers for diagnosis and treatment. This research is not only vital for understanding cancer biology but also for developing targeted therapies that can restore normal PP2A activity, offering hope for more effective cancer treatment strategies.
