Analytical Data
-
Gene name
PPP2R1B
- Application
-
Alternative Names
2AAB_HUMAN; beta isoform of regulatory subunit A; protein phosphatase 2; PP2A A beta; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta; PP2A; subunit A; PR65 beta isoform; PP2A; subunit A; R1 beta isoform; PPP2R1B; PPP4R1; PR65B; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); beta isoform; protein phosphatase 2 (formerly 2A); regulatory subunit A; beta isoform; Protein phosphatase 2; regulatory subunit A; beta; Protein phosphatase 2; structural/regulatory subunit A; beta; protein phosphatase 2; structural/regulatory subunit A; beta isoform; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A; beta isoform; serine/threonine protein phosphatase 2A; 65 kDa regulatory subunit A; beta isoform; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P30154
-
Expression Region
2-601 aa
-
AA Sequence
AGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL A
-
Molecular Weight
66.2 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP2R1B, a gene encoding the B regulatory subunit of protein phosphatase 2A (PP2A), plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Mutations and alterations in PPP2R1B have been implicated in the development of several cancers, making it a significant focus of cancer research. Understanding the function and regulation of PPP2R1B can provide insights into tumorigenesis and the potential for therapeutic interventions. Research has shown that the deregulation of PP2A activity, often due to aberrations in its regulatory subunits like PPP2R1B, contributes to oncogenic signaling pathways, highlighting the importance of this protein in maintaining cellular homeostasis. As a result, studying recombinant PPP2R1B proteins can aid in elucidating the molecular mechanisms underlying its role in cancer and help identify potential biomarkers for diagnosis and treatment. This research is not only vital for understanding cancer biology but also for developing targeted therapies that can restore normal PP2A activity, offering hope for more effective cancer treatment strategies.
