Analytical Data
-
Gene name
PPP1R42
- Application
-
Alternative Names
DTR; Leucine-rich repeat-containing protein 67; LRC67_HUMAN; lrrc67; PPP1R42; Protein phosphatase 1 regulatory subunit 42; Testis leucine-rich repeat; TLLR
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q7Z4L9
-
Expression Region
1-355 aa
-
AA Sequence
MVRLTLDLIA RNSNLKPRKE ETISQCLKKI THINFSDKNI DAIEDLSLCK NLSVLYLYDN CISQITNLNY ATNLTHLYLQ NNCISCIENL RSLKKLEKLY LGGNYIAVIE GLEGLGELRE LHVENQRLPL GEKLLFDPRT LHSLAKSLCI LNISNNNIDD ITDLELLENL NQLIAVDNQL LHVKDLEFLL NKLMKLWKID LNGNPVCLKP KYRDRLILVS KSLEFLDGKE IKNIERQFLM NWKASKDAKK ISKKRSSKNE DASNSLISNF KTMHHIVPVY YPQVGKPKLA FFSEIQRYPV NANASPESSE DYTKIIEMGN LSLKQSESLL TKNDVHEPHL FHNPEEKENL FVENE
-
Molecular Weight
35.4 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP1R42, also known as protein phosphatase 1 regulatory subunit 42, is a vital component in the regulation of protein phosphatase 1 (PP1), which plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and signal transduction. The study of PPP1R42 is particularly important because it can impact crucial physiological and pathological processes, including cancer progression, neurodegenerative diseases, and cardiac functions. Recent research has highlighted its potential as a therapeutic target due to its involvement in modulating PP1 activity, which is pivotal in numerous signaling pathways. Understanding the structure and function of PPP1R42, especially through the study of recombinant protein, can provide insights into its regulatory mechanisms and interactions with other cellular partners. Furthermore, producing recombinant PPP1R42 allows for detailed biochemical and biophysical analyses, offering opportunities to identify small molecule inhibitors or modulators that could influence its activity. This research can pave the way for novel therapeutic strategies aimed at diseases where PPP1R42 dysfunction is implicated. As such, the study of PPP1R42's role within the PP1 complex is not only crucial for fundamental biological understanding but also holds significant promise for clinical applications.
