Analytical Data
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Gene name
Mcu
- Application
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Alternative Names
Mcu；C10orf42；CCDC109A；Calcium uniporter Protein. mitochondrial
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3UMR5
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Expression Region
50-350aa
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AA Sequence
AHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHEDAATLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLKQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE
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Molecular Weight
39.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MCU (Mitochondrial Calcium Uniporter) is a crucial protein that facilitates the transport of calcium ions into the mitochondria, playing a significant role in regulating cellular calcium homeostasis and energy metabolism. The study of MCU recombinant proteins has gained traction due to the essential functions of mitochondrial calcium in various physiological processes, including ATP production, apoptosis, and metabolic signaling. Furthermore, disturbances in calcium uptake by mitochondria have been implicated in numerous pathologies, such as neurodegenerative diseases, cancer, and cardiovascular disorders. Recombinant MCU proteins are being researched to better understand their structure, function, and regulatory mechanisms. By producing and studying these proteins, researchers aim to uncover the molecular dynamics of MCU and its interactions with other mitochondrial components. This knowledge can pave the way for developing targeted therapies that address mitochondrial dysfunctions associated with various diseases. Furthermore, with advancements in techniques like cryo-electron microscopy and X-ray crystallography, scientists are now able to elucidate the intricate architecture of MCU and its functional implications in live cells. This research is not only significant for advancing our understanding of mitochondrial biology but also for addressing the broader implications of calcium signaling in health and disease.
