Analytical Data
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Gene name
C11orf65
- Application
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Alternative Names
C11orf65Uncharacterized Protein C11orf65
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NCR3
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Expression Region
1-313aa
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AA Sequence
MPWKEESEFT KQDKAARVIQ QAWKSFLNVA IFQHFKSLID LRRQGEPRQI VKYINPKEAE LLDAAAGIHV RFRLGGVKFP PDIYYKIFTH RPIEDLCANS PRNYAKLPAK HTSHNKNDHL QEEDHSGWYH RIENNGWRPV SDTFWLSTDG MVVEDKKESE FHFSKLKRRQ DLEKKRKLRK IEWMRQMYYS GSLEAKSTHH ETLGLIHTAT KGLIRAFEDG GIDSVMEWEV DEVLNWTNTL NFDEYIASWK EIATSNSSAN FKGFRFNQAQ KNIYNYGGDI SKMQMGIPDD TYYENVYQEP NVTRLTPDST YGL
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Molecular Weight
36.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C11orf65, a gene located on chromosome 11, has emerged as a notable subject of research in the field of genetics and molecular biology due to its association with several neurological disorders, particularly those affecting retinal function and cellular metabolism. Mutations in this gene have been linked to inherited recessive conditions such as retinitis pigmentosa and other retinal degenerative diseases, highlighting its significance in vision-related pathologies. The encoded protein, which is thought to play a critical role in mitochondrial function and cellular bioenergetics, has been of particular interest in understanding the underlying mechanisms of these diseases. Recent studies suggest that C11orf65 may be involved in mitochondrial dynamics, including processes like mitochondrial fusion and fission, which are crucial for maintaining mitochondrial health and efficient energy production. Furthermore, research into the recombinant protein of C11orf65 aims to elucidate its structure and function, providing insights into its role in cellular processes and its potential as a therapeutic target. By characterizing this protein, scientists hope to develop strategies for intervention in associated retinal diseases and to enhance our understanding of mitochondrial-related dysfunctions. Overall, the exploration of C11orf65 and its recombinant protein is pivotal in uncovering new avenues for diagnosis and treatment in the context of genetic retinal disorders and broader mitochondrial diseases.
