Analytical Data
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Gene name
ELAM1
- Application
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Alternative Names
ELAM1；ELAM1；；E-selectin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P16581
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Expression Region
22-556aa
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AA Sequence
WSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYW IGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKD VGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSG LKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMET MQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFD CEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSP AGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTA LSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWD NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHG STQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFA CPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIP
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Molecular Weight
60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ELAM1, or endothelial leukocyte adhesion molecule 1, is a cell adhesion molecule that plays a crucial role in the inflammatory response by mediating the adhesion of leukocytes to endothelial cells. This molecule is primarily expressed on the surface of endothelial cells and is integral to the recruitment of immune cells to sites of inflammation, which is essential for effective immune surveillance and tissue repair. Dysregulation of ELAM1 expression is associated with various pathological conditions, including atherosclerosis, chronic inflammation, and cancer metastasis. Consequently, researchers have focused on the study of ELAM1 recombinant protein to better understand its structural and functional properties, and to explore its potential as a therapeutic target. Recombinant ELAM1 protein can be used in various experimental setups to elucidate its role in cell signaling pathways and to determine its interactions with other molecules involved in the inflammatory response. Additionally, the development of ELAM1-based therapeutics holds promise for modulating immune responses in disease settings, potentially leading to new strategies for treating inflammatory disorders or enhancing cancer immunotherapy. Understanding the biology of ELAM1 and its recombinant forms may pave the way for innovative treatments that can harness or inhibit inflammatory processes in diverse clinical contexts.
