Analytical Data
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基因名
PPIB
- Application
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别名
AA408962; AA553318; AI844835; Cphn 2; Cphn2; Cyclophilin B; Cyclophilin like protein; CyP 20b; CYP S1; CYP-S1; CYPB; EC 5.2.1.8; MGC14109; MGC2224; OI9; peptidyl prolyl cis trans isomerase B; Peptidyl prolyl cis trans isomerase B precursor; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); Peptidylprolyl isomerase B; PPIase; PPIase B; Ppib; PPIB_HUMAN; Rotamase; Rotamase B; S cyclophilin; S-cyclophilin; SCYLP
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P23284
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表达区间
34-216 aa
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氨基酸序列
DEKKKGP KVTVKVYFDL RIGDEDVGRV IFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR KVESTKTDSR DKPLKDVIIA DCGKIEVEKP FAIAKE
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分子量
23.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on PPIB (Peptidylprolyl Isomerase B) recombinant protein is anchored in its significant role in protein folding and cellular stress responses. PPIB, also known as cyclophilin B, is a member of the cyclophilin family and functions as a peptidyl-prolyl cis-trans isomerase, facilitating the proper folding of proteins by catalyzing the isomerization of proline residues within polypeptides. This enzymatic activity is crucial for various biological processes, including immunological responses, cellular signaling, and apoptosis. Aberrant expression of PPIB has been associated with several diseases, including neurodegenerative disorders and cancers, making it a target of interest for therapeutic interventions. Additionally, the recombinant production of PPIB allows for further investigation into its structural characteristics, functional dynamics, and interactions with other biomolecules. Understanding PPIB's mechanism and optimizing its production can lead to advancements in both basic research and clinical applications, including the development of novel drugs and biotechnological products aimed at ameliorating diseases where protein misfolding is implicated. The exploration of PPIB’s role in protein stability and cellular health is therefore a critical area of study in molecular biology and biochemistry.
