Analytical Data
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Gene name
UL49
- Application
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Alternative Names
UL49；C6orf150；MB21D1；Cyclic GMP-AMP synthase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P89468
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Expression Region
170-300aa
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AA Sequence
QGLAKKLHFSTAPPSPTAPWTPRVAGFNKRVFCAAVGRLAATHARLAAVQLWDMSRPHTDEDLNELLDLTTIRVTVCEGKNLLQRANELVNPDAAQDVDATAAARGRPAGRAAATARAPARSASRPRRPLE
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Molecular Weight
17.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UL49, a conserved protein found in various herpesviruses, plays a crucial role in the virus life cycle, particularly in the assembly and egress of viral particles. Research into UL49 has gained significant attention due to its involvement in modulating host immune responses and its potential as a target for therapeutic intervention. Studies have shown that UL49 interacts with viral and cellular proteins, influencing the formation of the viral envelope and facilitating the transport of viral components within infected cells. Additionally, its ability to evade or counteract host immune defenses underscores its importance in viral pathogenesis. The exploration of UL49's structure and function is essential for understanding herpesvirus biology and developing novel antiviral strategies. Recent advances in recombinant protein technology have enabled the production of UL49 for detailed biochemical and biophysical characterization, paving the way for studies aimed at unraveling its mechanisms of action and identifying potential inhibitors. As such, UL49 not only serves as a vital component of the herpesvirus lifecycle but also represents a promising focus for the development of antiviral therapies and vaccines, highlighting the importance of continued research in this area.
