Analytical Data
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Gene name
EFNA1
- Application
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Alternative Names
EFNA1；EPLG1；Ephrin-A1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20827
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Expression Region
19-182aa
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AA Sequence
DR HTVFWNSSNP KFRNEDYTIH VQLNDYVDII CPHYEDHSVA DAAMEQYILY LVEHEEYQLC QPQSKDQVRW QCNRPSAKHG PEKLSEKFQR FTPFTLGKEF KEGHSYYYIS KPIHQHEDRC LRLKVTVSGK ITHSPQAHDN PQEKRLAADD PEVRVLHSIG HS
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Molecular Weight
46 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EFNA1, or Ephrin-A1, is a member of the ephrin family, which plays critical roles in various biological processes including cell communication, neuronal development, and angiogenesis. These proteins are essential for the functioning of Eph receptors, which are crucial in mediating bidirectional signaling pathways that influence cell positioning, movement, and tissue morphogenesis. The study of EFNA1 is particularly relevant in the context of cancer, where its expression patterns may contribute to tumor progression and metastasis. Aberrant EFNA1 signaling has been implicated in several malignancies, often correlating with poor prognosis and tumor aggressiveness. Furthermore, the investigation of EFNA1 recombinant protein offers valuable insights into its structure-function relationships, potential therapeutic applications, and interactions with Eph receptors. As researchers continue to explore the multifaceted roles of EFNA1 in both physiological and pathological contexts, the development of recombinant EFNA1 proteins serves as a crucial tool for elucidating its mechanisms of action and therapeutic potential in targeted cancer treatments and regenerative medicine. This research is paving the way for innovative strategies to manipulate EFNA1 signaling pathways for clinical benefits, providing a foundation for developing new therapeutic interventions in diseases where EFNA1 plays a pivotal role.
