Analytical Data
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Gene name
PPP2R2C
- Application
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Alternative Names
PPP2R2C；Immediate early response gene 5 Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y2T4
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Expression Region
1-447aa
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AA Sequence
MGEDTDTRKINHSFLRDHSYVTEADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH
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Molecular Weight
58.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP2R2C, or Protein Phosphatase 2 Regulatory Subunit B’gamma, is a critical component of the protein phosphatase 2A (PP2A) complex, which plays a significant role in various cellular processes, including cell growth, division, and apoptosis. Alterations in the regulation of PP2A have been implicated in numerous diseases, particularly in cancer, where its dysfunction can lead to aberrant signaling pathways. The study of PPP2R2C is particularly important due to its potential as a therapeutic target and biomarker for cancer diagnostics. Recent research has focused on understanding the molecular mechanisms underlying PPP2R2C’s function and its interactions within the PP2A complex, revealing its involvement in modulating phosphatase activity and influencing cellular responses to stress and growth signals. Investigating the structural characteristics of recombinant PPP2R2C proteins has provided insights into its regulatory roles and interaction with other cellular partners. As the landscape of targeted cancer therapies continues to evolve, elucidating the precise function and regulation of PPP2R2C is crucial for developing novel therapeutic strategies aimed at restoring normal cellular signaling in cancerous cells. This ongoing research into PPP2R2C not only enhances our understanding of PP2A regulation but also paves the way for innovative approaches in cancer treatment and prevention, highlighting the importance of continuing to explore its biochemical properties and physiological relevance in human health.
