Analytical Data
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基因名
BRWD1
- Application
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别名
Bromodomain and WD repeat domain containing Protein 1; Bromodomain and WD repeat-containing Protein 1; Brwd1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NSI6
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表达区间
1-120aa
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氨基酸序列
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKGTLI
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分子量
40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRWD1, or Bromodomain and WD Repeat Domain Containing 1, is a protein that has garnered significant attention in the field of molecular biology due to its essential role in various cellular processes, including transcription regulation, cell differentiation, and maintenance of genome integrity. This protein is characterized by the presence of bromodomains, which facilitate the recognition and binding of acetylated lysine residues on histones, thus influencing chromatin dynamics and gene expression. Dysregulation of BRWD1 has been implicated in several diseases, including cancer, making it a target of interest for therapeutic interventions. Recent studies have focused on the structural and functional characterization of BRWD1, including the development of recombinant forms of the protein to elucidate its mechanistic roles. The production of BRWD1 recombinant protein enables researchers to investigate its interactions with other cellular components and to assess its potential as a biomarker or therapeutic target. Understanding the precise functions and regulatory mechanisms of BRWD1 not only enhances our knowledge of epigenetic regulation but also contributes to the identification of new strategies for disease treatment, particularly in contexts where BRWD1 function is compromised. Through this research, advancements in biotechnology and medicine can be achieved, leading to improved outcomes for patients affected by BRWD1-related disorders.












