Analytical Data
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基因名
OSMR
- Application
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别名
OSMR；OSMRB；Oncostatin-M-specific receptor subunit beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99650
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表达区间
28-739aa
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氨基酸序列
ERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETS NVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPN FWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNV SCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMK GIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTL FESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNL THRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMM QYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLE AAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDK PSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPE NKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNV GPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSD NPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEK AVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSAT FTKVTTPDEHSSVDHHHHHH
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分子量
82 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSMR (Oncostatin M receptor) is a member of the class I cytokine receptor family and plays a crucial role in mediating the effects of oncostatin M, a cytokine involved in various physiological and pathological processes, including inflammation, cancer, and tissue repair. The significance of OSMR in these processes has sparked interest in its potential as a therapeutic target. Research has revealed that OSMR is involved in several signaling pathways that regulate cell proliferation, differentiation, and survival, making it a critical player in diseases such as rheumatoid arthritis and certain cancers. Due to its pivotal role in immune responses and its association with disease progression, the production of recombinant OSMR proteins has become essential for understanding its biological functions and interactions with other signaling molecules. This has facilitated the development of specific inhibitors and monoclonal antibodies aimed at modulating its activity for therapeutic interventions. Recent studies have demonstrated that manipulating OSMR signaling can positively impact disease outcomes, thereby highlighting the importance of ongoing research into recombinant OSMR proteins to uncover new treatment strategies and improve patient care. Through advanced techniques in protein engineering and expression systems, researchers are continuously exploring the structure-function relationships of OSMR, paving the way for innovative solutions to tackle diseases associated with dysregulated OSMR activity. The insights gained from these studies could lead to groundbreaking advancements in the field of immunotherapy and regenerative medicine.
