Analytical Data
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基因名
Hsd17b13
- Application
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别名
Hsd17b13；SCDR9；SDR16C3；17-beta-hydroxysteroid dehydrogenase 13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z5P4
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表达区间
1-300aa
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氨基酸序列
MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGR QTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEI YRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFW ITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLT SELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGI LTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSD17B13, a member of the 17β-hydroxysteroid dehydrogenase family, has gained significant attention in recent years due to its emerging role in lipid metabolism and liver function. Initially identified for its involvement in steroid hormone biosynthesis, HSD17B13 has been linked to various metabolic disorders, including non-alcoholic fatty liver disease (NAFLD) and liver cirrhosis. Genetic studies have revealed that specific single nucleotide polymorphisms (SNPs) in the HSD17B13 gene are associated with a reduced risk of liver diseases, suggesting a protective role against hepatic injury. Consequently, understanding the function and regulation of HSD17B13 could provide insights into potential therapeutic targets for liver diseases. Researchers are currently focusing on the characterization of recombinant HSD17B13 protein to elucidate its enzymatic activity, substrate specificity, and interactions with other metabolic pathways. This research is crucial for uncovering the mechanisms by which HSD17B13 influences lipid homeostasis and liver health, ultimately paving the way for novel interventions in liver-related disorders. The investigation of recombinant HSD17B13 protein will further enhance our understanding of its biological significance and open up new avenues for the development of strategies to mitigate liver disease progression.
