Analytical Data
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基因名
PMS2L5
- Application
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别名
PMS2P5; PMS2L5; PMS4; PMS7; Postmeiotic segregation increased 2-like protein 5; Postmeiotic segregation increased protein 4; Postmeiotic segregation increased protein 7; Putative postmeiotic segregation increased 2 pseudogene 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A8MQ11
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表达区间
1-134 aa
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氨基酸序列
MWGRRRKLRR LNDVTISTCH VSAKVGTRLV FDHDGKIIQK TPYPHPRGTT VSVKQLFSTL PVRHKEFQRN IKKKRACFPF AFCRDCQFLE GSPAMLPVQP AKLTPRSTPP HPCSLEDNVI TVFSSVKNGP GSSR
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分子量
15.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PMS2L5 is a member of the PMS (Postmeiotic Segregation Increased 2) gene family, which plays a crucial role in DNA repair and maintaining genomic stability. The significance of this gene has been underscored by its involvement in the mismatch repair (MMR) pathway, which is essential for repairing DNA replication errors that could lead to mutations and genomic instability. Research has shown that defects in MMR genes like PMS2L5 can lead to a higher predisposition to various cancers, particularly colorectal cancer, highlighting the importance of understanding its functional mechanisms. Given the emerging role of PMS2L5 in both hereditary and sporadic forms of cancer, ongoing studies aim to elucidate its structure and catalytic properties through recombinant protein expression and purification methods. By generating and characterizing recombinant PMS2L5 protein, researchers can better understand its biochemical activities, interaction partners, and overall contribution to cellular processes involved in DNA repair. This knowledge may provide insights into the development of targeted therapies for cancers associated with MMR deficiencies. Overall, the investigation of PMS2L5 as a recombinant protein serves as a vital step in unraveling its biological roles and therapeutic potential in cancer research.
