Analytical Data
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基因名
PLEK
- Application
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别名
FLJ27168; OTTHUMP00000159962; p47; Platelet 47 kDa protein; Platelet and leukocyte C kinase substrate; Platelet P47; Platelet p47 protein; Pleckstrin; PLEK; PLEK_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08567
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表达区间
1-350 aa
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氨基酸序列
MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNSPKGMIPL KGSTLTSPCQ DFGKRMFVFK ITTTKQQDHF FQAAFLEERD AWVRDIKKAI KCIEGGQKFA RKSTRRSIRL PETIDLGALY LSMKDTEKGI KELNLEKDKK IFNHCFTGNC VIDWLVSNQS VRNRQEGLMI ASSLLNEGYL QPAGDMSKSA VDGTAENPFL DNPDAFYYFP DSGFFCEENS SDDDVILKEE FRGVIIKQGC LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGAEDPLGAI HLRGCVVTSV ESNSNGRKSE EENLFEIITA DEVHYFLQAA TPKERTEWIR AIQMASRTGK
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分子量
40.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLEK (Pleckstrin) is a crucial protein involved in cellular signaling and cytoskeletal organization, particularly within immune and hematopoietic cells. Its research background traces back to its initial identification in platelets, where it plays a pivotal role in actin cytoskeleton rearrangement upon activation, influencing platelet aggregation and thrombus formation. Over the years, studies have revealed that PLEK is also implicated in various cellular processes, including cell migration, adhesion, and differentiation, making it a key player in both normal physiology and pathological conditions. The importance of PLEK extends into cancer research, where its aberrant expression has been correlated with tumor progression and metastasis, highlighting its potential as a therapeutic target. Additionally, PLEK's involvement in immune cell function underscores its significance in inflammatory responses and autoimmune diseases. Ongoing research aims to unravel the precise molecular mechanisms through which PLEK exerts its functions, leveraging advanced techniques in molecular biology and biochemistry. These insights could pave the way for novel interventions in diseases where PLEK is a contributing factor, ultimately enhancing our understanding of its role in health and disease.
