Analytical Data
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基因名
BNIP2
- Application
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别名
BCL2/adenovirus E1B 19 kDa Protein interacting Protein 2; BCL2/adenovirus E1B 19 kDa Protein-interacting Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12982
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表达区间
1-314aa
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氨基酸序列
MEGVELKEEW QDEDFPIPLP EDDSIEADIL AITGPEDQPG SLEVNGNKVR KKLMAPDISL TLDPSDGSVL SDDLDESGEI DLDGLDTPSE NSNEFEWEDD LPKPKTTEVI RKGSITEYTA AEEKEDGRRW RMFRIGEQDH RVDMKAIEPY KKVISHGGYY GDGLNAIVVF AVCFMPESSQ PNYRYLMDNL FKYVIGTLEL LVAENYMIVY LNGATTRRKM PSLGWLRKCY QQIDRRLRKN LKSLIIVHPS WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQVD QELNGKQDEP KNEQ
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分子量
36 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BNIP2 (Bcl-2/adenovirus E1B 19 kDa interacting protein 2) is a member of the BH3-only protein family, known for its role in regulating apoptosis and autophagy. Research into BNIP2 has gained significance due to its involvement in various cellular processes and disease states, particularly in cancer and neurodegenerative disorders. BNIP2 interacts with key proteins involved in mitochondrial function and cell survival, highlighting its potential as a therapeutic target. Recent studies have focused on characterizing the structure and function of recombinant BNIP2 protein to elucidate its mechanisms of action. The production of BNIP2 as a recombinant protein allows for comprehensive in vitro studies, enabling researchers to explore its interactions with other Bcl-2 family proteins and membrane dynamics. Understanding BNIP2's role in cellular homeostasis could provide insights into the development of novel treatments for diseases where apoptosis is dysregulated. Collectively, ongoing investigations on BNIP2 aim to unravel its contributions to cellular signaling pathways, making it a critical focus in the field of molecular biology and therapeutic research.
