Analytical Data
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基因名
PLD1
- Application
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别名
80K-H protein; AGE-binding receptor 2; AGE-R2; G19P1; GLU2B_HUMAN; Glucosidase 2 subunit beta; Glucosidase II beta subunit; Glucosidase II subunit beta; Hepatocystin; PCLD; PKCSH; PLD1; PRKCSH; Protein kinase C substrate 60.1 kDa protein heavy chain; Protein kinase C substrate 80 Kda protein; Protein kinase C substrate 80K-H; Protein kinase C substrate; 80 Kda protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14314
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表达区间
15-302 aa
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氨基酸序列
VEVKRPRGVSLTNHHFYDESKPFTCLDGSATIPFDQVNDDYCDCKDGSDEPGTAACPNGSFHCTNTGYKPLYIPSNRVNDGVCDCCDGTDEYNSGVICENTCKEKGRKERESLQQMAEVTREGFRLKKILIEDWKKAREEKQKKLIELQAGKKSLEDQVEMLRTVKEEAEKPEREAKEQHQKLWEEQLAAAKAQQEQELAADAFKELDDDMDGTVSVTELQTHPELDTDGDGALSEAEAQALLSGDTQTDATSFYDRVWAAIRDKYRSEALPTDLPAPSAPDLTEPKE
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分子量
59.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLD1 (phospholipase D1) is an important enzyme involved in various cellular processes, including membrane dynamics, signal transduction, and cell migration. It plays a crucial role in the regulation of phosphatidic acid production, which acts as a lipid messenger in numerous signaling pathways. Research into PLD1 has gained significant attention due to its implications in cancer biology, where altered PLD1 activity is associated with tumor progression and metastasis. Additionally, PLD1 has been implicated in other pathological conditions, such as cardiovascular diseases and neurodegenerative disorders. The enzymatic activity of PLD1 is regulated by various factors, including GTPases, phosphoinositides, and protein-protein interactions, which highlight its complex regulatory mechanisms. Recombinant PLD1 protein has been produced for structural and functional studies, enabling researchers to explore its role in cellular signaling and understand the molecular basis of its regulation. This understanding can pave the way for the development of therapeutic strategies targeting PLD1 in diseases where its dysregulation contributes to pathophysiology. Overall, the study of PLD1 and its recombinant protein offers valuable insights into fundamental cellular processes and potential clinical applications.
