Analytical Data
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Gene name
BLOC1S1
- Application
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Alternative Names
BLOC1S1; BLOS1; GCN5L1; RT14Biogenesis of lysosome-related organelles complex 1 subunit 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P78537
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Expression Region
1-153aa
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AA Sequence
MAPGSRGERS SFRSRRGPGV PSPQPDVTML SRLLKEHQAK QNERKELQEK RRREAITAAT CLTEALVDHL NVGVAQAYMN QRKLDHEVKT LQVQAAQFAK QTGQWIGMVE NFNQALKEIG DVENWARSIE LDMRTIATAL EYVYKGQLQS APS
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Molecular Weight
40.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BLOC1S1, a crucial component of the BLOC-1 (Biogenesis of Lysosome-related Organelles Complex 1), plays a significant role in intracellular trafficking and organelle biogenesis, particularly in melanocytes and platelets. Research into BLOC1S1 has gained prominence due to its association with Hermansky-Pudlak syndrome, a genetic disorder characterized by albinism, hemorrhagic diathesis, and pulmonary fibrosis, which arises from mutations in genes involved in lysosome-related organelle biogenesis, including BLOC1S1. Studies have demonstrated that BLOC1S1 is integral to the formation and function of various organelles, influencing processes such as pigmentation and immune responses. Investigating BLOC1S1 not only enhances our understanding of cellular mechanisms but also holds potential therapeutic implications for the aforementioned syndrome and related diseases. Moreover, the protein's involvement in endosomal trafficking and its interaction with other components of the BLOC-1 complex underscore its importance in maintaining cellular homeostasis. Given these factors, ongoing research is focused on elucidating the functional pathways associated with BLOC1S1, investigating its structural properties, and exploring its potential as a biomarker or therapeutic target in conditions linked to organelle dysfunction.
