Analytical Data
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Gene name
Setd4
- Application
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Alternative Names
Setd4；C21orf18；C21orf27；SET domain-containing Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NVD3
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Expression Region
1-307aa
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AA Sequence
MQKGKGRTSRIRRRKLCGSSESRGVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGR GLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSPLLALCTFLVSEKHA GHRSLWKPYLEILPKAYTCPVCLEPEVVNLLPKSLKAKAEEQRAHVQEFFASSRDFFSSL QPLFAEAVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHSPH VQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDNQRLFLEYGFVSVHNPHACVYVSR GWNQLCS
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Molecular Weight
50.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Setd4 is a member of the SET domain-containing protein family, which is known for its role as a methyltransferase, specifically involved in the methylation of histones and non-histone proteins. This post-translational modification plays a critical role in regulating gene expression, chromatin structure, and various cellular processes. Recent studies have highlighted the importance of Setd4 in diverse biological contexts, including stem cell regulation, development, and oncogenesis. It has been implicated in various cancers, where its dysregulation can influence tumor growth and metastasis. Understanding the molecular mechanisms by which Setd4 exerts its effects is crucial for uncovering its potential as a therapeutic target. The study of recombinant Setd4 proteins has enabled researchers to analyze their biochemical properties, substrate specificities, and interaction networks, providing insights into the functional landscape of this methyltransferase. As research progresses, the characterization of Setd4 and its associated pathways may reveal novel strategies for cancer treatment and other diseases linked to epigenetic alterations.
