Analytical Data
-
基因名
MYCN
- Application
-
别名
MYCN；BHLHE37；NMYC；N-myc proto-oncogene Protein
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P04198
-
表达区间
1-464aa
-
氨基酸序列
MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIW KKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLG GLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSP GAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKR EPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHK ALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTIT VRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKI KSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSS FLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQAR QQQLLKKIEHARTC
-
分子量
77 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The MYCN protein, a member of the MYC oncogene family, is primarily involved in cell proliferation and differentiation. It plays a crucial role in neuroblastoma, a common pediatric cancer characterized by the overexpression of MYCN. Research has shown that MYCN amplification is associated with poor prognosis and aggressive tumor behavior, making it a significant focus in cancer biology. Given its pivotal role in oncogenesis, understanding MYCN's structure and function is essential for developing targeted therapies. The generation of recombinant MYCN protein allows researchers to investigate its biological activities and interactions with other molecular partners in a controlled environment. This approach aids in elucidating the mechanisms through which MYCN drives tumorigenesis and identifies potential therapeutic targets. The study of MYCN recombinants has also led to insights into its role in transcription regulation and cellular signaling pathways, further cementing its status as a key player in cancer research. Therefore, the characterization of MYCN recombinant protein is vital for advancing our understanding of neuroblastoma and ultimately contributing to the development of new therapeutic strategies.
