Analytical Data
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基因名
Mxd1
- Application
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别名
Mxd1；MAD；Max dimerization Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q05195
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表达区间
1-221aa
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氨基酸序列
MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL
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分子量
25.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Mxd1, also known as Mad3, is a member of the Myc family of transcription factors, which play crucial roles in the regulation of cell growth, differentiation, and apoptosis. It functions primarily as a transcriptional repressor, modulating the expression of target genes involved in cellular proliferation and survival. Research on Mxd1 is significant due to its potential involvement in various human diseases, particularly cancer, where dysregulation of Myc family proteins is commonly observed. The ability of Mxd1 to inhibit Myc-driven transcription suggests that Mxd1 could act as a tumor suppressor, making it a target of interest in cancer research. Additionally, Mxd1 has been implicated in the regulation of metabolic processes and stress responses within cells. The study of recombinant Mxd1 protein allows researchers to investigate its structure, function, and interactions with other cellular components, contributing to a better understanding of its biological roles. Techniques such as protein expression in heterologous systems and functional assays are employed to characterize Mxd1’s activity and explore its potential as a therapeutic target. Understanding the intricate balance between Mxd1 and its Myc counterparts could reveal new insights into tumorigenesis and pave the way for novel therapeutic strategies in cancer treatment.
