Analytical Data
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基因名
ITGA5
- Application
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别名
ITGA5；FNRA；Integrin alpha-5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08648
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表达区间
42-995aa
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氨基酸序列
FNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVL QGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQW FGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAP CRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQI AESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVA GVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLD DLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGR FGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQ VLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRP IVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSIG FTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYL RNESEFRDKLSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQI LLDCGEDNICVPDLQLEVFGEQNHVYLGDKNALNLTFHAQNVGEGGAYEA ELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAGA SLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQ VTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSIS QGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQ QKREAPSRSSASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVW AKTFLQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKA EGSYVDHHHHHH
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分子量
105 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ITGA5, or Integrin Alpha 5, is a vital protein that plays a crucial role in cell adhesion, migration, and signaling processes within the extracellular matrix (ECM). As a member of the integrin family, ITGA5 forms partnerships with other subunits to create functional heterodimers, most notably with integrin beta-1 (ITGB1), resulting in the formation of the fibronectin receptor, which is essential for various physiological processes including wound healing, embryogenesis, and tissue repair. Dysregulation of ITGA5 has been implicated in several pathological conditions, such as cancer metastasis, where increased expression is often associated with enhanced tumor invasion and poor prognosis. Additionally, ITGA5 has been studied for its potential role in fibrotic diseases and cardiovascular disorders. Research focusing on the recombinant expression of ITGA5 protein is crucial for understanding its structural and functional properties, as well as its interactions with other biomolecules. The availability of recombinant ITGA5 allows scientists to explore its biochemical pathways, develop targeted therapies, and investigate its role as a biomarker in disease contexts. Moreover, the ability to produce ITGA5 in a laboratory setting enhances the feasibility of large-scale studies and facilitates the advancement of therapeutic strategies that could mitigate the adverse effects associated with its aberrant expression. Overall, the study of ITGA5 recombinant proteins is fundamental to unraveling the complexities of cell-ECM interactions and developing innovative approaches for treating diseases linked to integrin dysfunction.
