Analytical Data
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基因名
PIH1D2
- Application
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别名
PIH1D2; PIH1 domain-containing protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WWB5
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表达区间
1-315 aa
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氨基酸序列
METSSKGLLT QVTQFWNLLD DLAQSDPEGY EKFIQQQLKE GKQLCAAPEP QLCLQTRILK PKEKILFINL CQWTRIPAPQ STTHPVPLTV GKPEDTTEIS DAYTVIDVAY NPDVLHAAEK DQVKKNQLIQ MAMKCIEEKF QFTLSHSYHI TKFRIKGSIQ RMKQNLMGIQ TDSIDLREKM RRELTLGQIR SSTMSNPDHF PQLLLPKDQV SGKAVCLIEE ISSTEIQVEM KMPAYELKIV HDHSEKPLKI ELKVELPGIN SVSLCDLSVS EDDLLIEVSE KYRLHLNLPK LIDTEMTTAK FIKEKSTLII TMPLV
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分子量
35.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The PIH1D2 protein is of significant interest in the field of molecular biology and biochemistry due to its potential role in various cellular processes, including protein homeostasis and the regulation of the proteasome, a key component in the degradation of ubiquitinated proteins. Research has shown that PIH1D2 is involved in the assembly and function of the proteasome lid subcomplex, thereby impacting the pathway of protein degradation, which is crucial for maintaining cellular protein levels and quality control. Dysregulation of this process can contribute to various diseases, including cancer and neurodegenerative disorders. Additionally, PIH1D2 has been implicated in several signaling pathways and cellular responses, making it a potential target for therapeutic intervention. Understanding the structure and function of the PIH1D2 protein through recombinant protein studies is essential for unraveling its mechanistic roles in these pathways. The exploration of PIH1D2's interactions with other proteins and its contributions to larger protein complexes may provide valuable insights into its biological significance and potential implications in health and disease, paving the way for novel treatment strategies that harness its functions. Thus, the study of PIH1D2 not only enhances our comprehension of fundamental cellular processes but also offers prospects for innovative therapeutic developments.
