Analytical Data
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Gene name
C1QTNF5
- Application
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Alternative Names
C1QTNF5；CTRP5；Complement C1q tumor necrosis factor-related Protein 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXJ0
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Expression Region
16-243aa
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AA Sequence
SPPLD DNKIPSLCPG HPGLPGTPGH HGSQGLPGRD GRDGRDGAPG APGEKGEGGR PGLPGPRGDP GPRGEAGPAG PTGPAGECSV PPRSAFSAKR SESRVPPPSD APLPFDRVLV NEQGHYDAVT GKFTCQVPGV YYFAVHATVY RASLQFDLVK NGESIASFFQ FFGGWPKPAS LSGGAMVRLE PEDQVWVQVG VGDYIGIYAS IKTDSTFSGF LVYSDWHSSP VFA
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Molecular Weight
25.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C1QTNF5, also known as complement component 1 Q subcomponent-binding protein (C1qBP), is a multifunctional protein that has garnered significant attention in the field of molecular biology and medicine due to its involvement in various physiological and pathological processes. It is primarily expressed in the eye and has been implicated in the pathogenesis of retinal diseases, particularly in conditions such as age-related macular degeneration and diabetic retinopathy. Research has indicated that C1QTNF5 plays a crucial role in the regulation of inflammation, the immune response, and cellular metabolism, which are all vital for maintaining retinal health. Additionally, mutations in the C1QTNF5 gene have been associated with a rare form of retinal dystrophy, highlighting its importance in visual function. Studies aimed at characterizing C1QTNF5, including its structure, binding partners, and signaling pathways, are essential for understanding its role in disease mechanisms. In this context, the development of recombinant C1QTNF5 protein offers a powerful tool for investigating its biological functions and potential therapeutic applications. By providing insights into the molecular interactions and pathways mediated by C1QTNF5, this research could pave the way for novel strategies to treat retinal diseases and improve patient outcomes.
