Analytical Data
-
Gene name
YOD1
- Application
-
Alternative Names
YOD1；HEL-220；Transitional endoplasmic reticulum ATPase
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q5VVQ6
-
Expression Region
1-348aa
-
AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMFGPAKGRHFGVHPAPGFPGGVSQQAA GTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVLQGLSSRTRVRELQGQIA AITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIIEEDQTRP RSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPA CAPEMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISI LSKFYQCEICVVDTQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPD PDTPPLTIFSSNDDIVLVQALELADEARRRRQFTDVNRFTLRCMVCQKGL TGQAEAREHAKETGHTNFGEV
-
Molecular Weight
41 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
YOD1, also known as Yod1 or YOD1-like protein, is a member of the deubiquitinating enzyme (DUB) family, which plays a crucial role in regulating protein stability and cellular processes by removing ubiquitin moieties from target proteins. Research into YOD1 has gained prominence due to its implications in various cellular functions and potential connections to diseases, including cancer and neurodegenerative disorders. It has been observed that YOD1 is involved in the endoplasmic reticulum-associated degradation (ERAD) pathway, where it aids in the removal of misfolded proteins from the endoplasmic reticulum, thus maintaining cellular homeostasis. Additionally, studies suggest that YOD1 could influence various signaling pathways by modulating the ubiquitination status of key regulatory proteins. The understanding of YOD1’s structure and function is increasingly vital, not only for elucidating its role in fundamental biological processes but also for the development of novel therapeutic strategies targeting dysfunctional DUBs in disease conditions. As the research community delves deeper into the molecular mechanisms by which YOD1 operates, it is hoped that breakthroughs may be achieved that leverage this knowledge toward innovative treatments and biomarker discovery.
