Cat: PA2000-5724

Recombinant Human AVEN Protein,GST

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Analytical Data

  • 基因名

    AVEN

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    MGC124011; OTTMUSP00000016129; PDCD12; Programmed cell death 12; RP23-52C15.2

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    GST-tag at N-terminal

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q9NQS1

  • 表达区间

    1-362aa

  • 氨基酸序列

    MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

  • 分子量

    64.9 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

AVEN (Apoptosis and Caspase Activation Inhibitor) is a protein that has garnered significant interest in the field of cancer research due to its role in regulating apoptosis and maintaining cell survival. Originally identified as a caspase inhibitor, AVEN is involved in cellular responses to stress and plays a critical role in the development and progression of various cancers. Studies have shown that AVEN can modulate apoptotic pathways, allowing cancer cells to evade programmed cell death, which contributes to tumor growth and resistance to therapy. Recent research has focused on the structural and functional characterization of AVEN, aiming to understand its molecular mechanisms and how it interacts with other proteins in apoptotic signaling pathways. This has led to explorations of AVEN as a potential therapeutic target; inhibiting its function might restore apoptotic processes in cancer cells, enhancing the efficacy of existing treatments. Furthermore, understanding AVEN's role could provide insights into resistance mechanisms in cancer therapies, paving the way for novel strategies in cancer treatment. Researchers are employing techniques such as recombinant protein expression and structural biology to elucidate AVEN's conformation and binding properties, which is critical for the development of small molecules or peptides that can disrupt its function. This emerging body of work highlights AVEN not only as a vital player in apoptosis regulation but also as a promising candidate for targeted cancer therapies, signifying a shift towards more personalized treatment options in oncology.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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