Analytical Data
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Gene name
TEAD1
- Application
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Alternative Names
TEAD1；TCF13；TEF1；Transcriptional enhancer factor TEF-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P28347
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Expression Region
1-426aa
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AA Sequence
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIY PPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARR KSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTF PGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPA PSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYS DPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQD DAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFV YRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETL LCMACVFEVSNSEHGAQHHIYRLVKD
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Molecular Weight
52 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TEAD1 (TEA Domain Transcription Factor 1) is a crucial transcription factor that plays a significant role in various biological processes, including cell proliferation, differentiation, and development. As a key mediator in the Hippo signaling pathway, TEAD1 interacts with the transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), regulating gene expression and cellular responses to growth signals. Dysregulation of TEAD1 and its interactions has been implicated in various diseases, particularly in cancer, where it contributes to increased proliferative signaling and oncogenic transcriptional programs. As researchers strive to elucidate the molecular mechanisms underlying TEAD1's functions, the production of recombinant TEAD1 protein provides a valuable tool for structural and functional studies. By generating and characterizing this protein, scientists can investigate its binding affinities, post-translational modifications, and interactions with binding partners. This research not only enhances our understanding of TEAD1's role in cellular contexts but also paves the way for potential therapeutic interventions targeting TEAD1 signaling pathways in diseases associated with its dysregulation. Thus, the study of TEAD1 recombinant protein is foundational to bridging basic research and clinical applications, thereby highlighting its significance in the field of molecular biology and therapeutic development.
