Analytical Data
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基因名
ATP6V1C2
- Application
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别名
ATP6C2; ATP6V1C2; ATPase H+ transporting lysosomal 42kDa V1 subunit C2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NEY4
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表达区间
1-427aa
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氨基酸序列
MSEFWLISAP GDKENLQALE RMNTVTSKSN LSYNTKFAIP DFKVGTLDSL VGLSDELGKL DTFAESLIRR MAQSVVEVME DSKGKVQEHL LANGVDLTSF VTHFEWDMAK YPVKQPLVSV VDTIAKQLAQ IEMDLKSRTA AYNTLKTNLE NLEKKSMGNL FTRTLSDIVS KEDFVLDSEY LVTLLVIVPK PNYSQWQKTY ESLSDMVVPR STKLITEDKE GGLFTVTLFR KVIEDFKTKA KENKFTVREF YYDEKEIERE REEMARLLSD KKQQYQTSCV ALKKGSSTFP DHKVKVTPLG NPDRPAAGQT DRERESEGEG EGPLLRWLKV NFSEAFIAWI HIKALRVFVE SVLRYGLPVN FQAVLLQPHK KSSTKRLREV LNSVFRHLDE VAATSILDAS VEIPGLQLNN QDYFPYVYFH IDLSLLD
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分子量
48.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ATP6V1C2 protein is a crucial component of the vacuolar ATPase (V-ATPase) complex, which is responsible for maintaining cellular homeostasis through the regulation of pH and membrane potential. This protein plays a significant role in various cellular processes, including endocytosis, protein trafficking, and bone resorption. Research into ATP6V1C2 has gained importance due to its implications in various diseases, such as cancer, where altered V-ATPase activity can affect tumor growth and metastasis. Additionally, ATP6V1C2 has been implicated in certain genetic disorders characterized by impaired acidification of cellular compartments. Understanding the structure and function of ATP6V1C2, including the effects of specific mutations, is crucial for elucidating its role in health and disease. Recent advances in recombinant protein technology have facilitated the production of ATP6V1C2 for biochemical and biophysical studies, enabling researchers to explore its interactions with other V-ATPase subunits and regulatory proteins. This research not only enhances our understanding of ATP6V1C2’s functional mechanisms but also opens avenues for the development of targeted therapeutic strategies aimed at modulating V-ATPase activity in disease contexts. Overall, the study of ATP6V1C2 as a recombinant protein holds potential for revealing novel insights into its biological significance and therapeutic potential.
