Analytical Data
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Gene name
GNaO1
- Application
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Alternative Names
GNaO1；Guanine nucleotide-binding Protein G(o) subunit alpha
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P18872
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Expression Region
2-354aa
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AA Sequence
GCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKTDSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
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Molecular Weight
42.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNaO1, a member of the GTPase family, plays a crucial role in cellular signaling pathways, particularly in the regulation of neurotransmitter release and synaptic plasticity. Recent studies have highlighted its involvement in various neurological disorders, including schizophrenia and bipolar disorder, making it a significant target for therapeutic intervention. The recombinant expression of GNaO1 in various model systems, such as bacteria and yeast, allows researchers to produce and purify this protein for in-depth functional studies. Understanding the structural and functional properties of GNaO1 helps elucidate its role in intracellular signaling and provides insights into its interactions with other proteins. Additionally, characterizing the protein’s binding affinity for GTP and GDP can shed light on its regulatory mechanisms and contribute to drug discovery efforts aimed at modulating its activity. Given its potential implications in neuropharmacology, the study of GNaO1 recombinant protein is essential for advancing our knowledge of molecular mechanisms underlying neurodevelopmental and psychiatric disorders.
