Analytical Data
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基因名
SLCO1B2
- Application
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别名
SLCO1B2；Oatp1b2；Slc21a10；Solute carrier organic anion transporter family member 1B2
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9JJL3
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表达区间
1-689aa
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氨基酸序列
MDQTQHPSKAAQPLRSEKTRHCDGFRIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALPHFFMGYYRYATENDISSLHNSTLTCLVNQTTSLTGTSPEIMEKGCEKGSNSYTWIYVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCIICSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEKQAPANLTGFLWSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNIEFYDCSCVSGSGFQKGNHSARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLGGILAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTPILLLYVALIYVMKRKMKRNDNKILENGRKFTDEGNPEPVNNNGYSCVPSDEKNSETPL
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分子量
76.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLCO1B2, part of the solute carrier organic anion transporter (SLCO) family, plays a crucial role in drug transport and metabolism. This protein is predominantly expressed in the liver and is responsible for the uptake of various endogenous compounds and therapeutic agents, including statins, corticosteroids, and certain chemotherapeutics. Its relevance in pharmacokinetics and pharmacodynamics makes it a significant target of research, especially concerning drug-drug interactions and variations in drug response among individuals. Genetic polymorphisms in the SLCO1B2 gene can alter the expression and function of the transporter, leading to differences in drug efficacy and safety profiles. Given the increasing importance of personalized medicine, characterizing SLCO1B2 through recombinant protein studies has gained momentum, as it helps in elucidating the molecular mechanisms underlying these variations. Furthermore, understanding SLCO1B2's interactions with drugs can significantly impact clinical decisions and therapeutic strategies, enhancing the drug development process and optimizing patient outcomes. Research on the recombinant form of SLCO1B2 facilitates advanced screening approaches for new drug candidates and aids in predicting potential pharmacokinetic interactions. Thus, the study of recombinant SLCO1B2 is pivotal for both basic pharmacology and the clinical management of therapies that rely on this transporter's functionality.
