Analytical Data
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Gene name
ATG13
- Application
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Alternative Names
ATG13; ATG13 autophagy related 13 homolog (S. cerevisiae); ATG13_HUMAN; Autophagy related 13
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75143
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Expression Region
1-517aa
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AA Sequence
METDLNSQDR KDLDKFIKFF ALKTVQVIVQ ARLGEKICTR SSSSPTGSDW FNLAIKDIPE VTHEAKKALA GQLPAVGRSM CVEISLKTSE GDSMELEIWC LEMNEKCDKE IKVSYTVYNR LSLLLKSLLA ITRVTPAYRL SRKQGHEYVI LYRIYFGEVQ LSGLGEGFQT VRVGTVGTPV GTITLSCAYR INLAFMSTRQ FERTPPIMGI IIDHFVDRPY PSSSPMHPCN YRTAGEDTGV IYPSVEDSQE VCTTSFSTSP PSQLSSSRLS YQPAALGVGS ADLAYPVVFA AGLNATHPHQ LMVPGKEGGV PLAPNQPVHG TQADQERLAT CTPSDRTHCA ATPSSSEDTE TVSNSSEGRA SPHDVLETIF VRKVGAFVNK PINQVTLTSL DIPFAMFAPK NLELEDTDPM VNPPDSPETE SPLQGSLHSD GSSGGSSGNT HDDFVMIDFK PAFSKDDILP MDLGTFYREF QNPPQLSSLS IDIGAQSMAE DLDSLPEKLA VHEKNVREFD AFVETLQ
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Molecular Weight
56.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ATG13 (autophagy-related 13) is a crucial regulatory protein involved in the autophagy process, a fundamental cellular mechanism for degrading and recycling cellular components. Autophagy plays a pivotal role in maintaining cellular homeostasis, responding to nutrient stress, and regulating immune responses. The interest in ATG13 has surged due to its involvement in various physiological processes and its potential implications in diseases. For instance, dysregulation of autophagy has been linked to cancer, neurodegenerative disorders, and metabolic diseases, highlighting the importance of understanding ATG13's function and regulation. Furthermore, ATG13 is known to interact with other autophagy-related proteins, forming complexes that initiate the autophagic machinery. This makes it a key component in studying the autophagy pathway's dynamics. The recombinant production of ATG13 enables researchers to explore its molecular interactions, post-translational modifications, and functional roles in autophagy in a controlled manner. As a result, studying recombinant ATG13 provides valuable insights into the mechanistic aspects of autophagy, paving the way for potential therapeutic strategies aimed at modulating this process in various diseases. The ongoing research into ATG13 and related autophagy pathways holds promise for uncovering novel targets for drug development, particularly in the context of cancer therapies and regenerative medicine.
