Analytical Data
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Gene name
UQCRQ
- Application
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Alternative Names
UQCRQ；Cytochrome b-c1 complex subunit 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14949
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Expression Region
1-82aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGREFGN LTRMRHVISY SLSPFEQRAY PHVFTKGIPN VLRRIRESFF RVVPQFVVFY LIYTWGTEEF ERSKRKNPAA YENDK
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UQCRQ, or Ubiquinol-Cytochrome c Reductase Complex Core Protein Q, is a crucial component of the mitochondrial electron transport chain, specifically found within Complex III. This protein plays a vital role in cellular respiration and energy production by facilitating electron transfer between ubiquinol and cytochrome c. Research on UQCRQ has garnered significant attention due to its implications in mitochondrial dysfunction, which is increasingly linked to various metabolic and neurodegenerative diseases. Mutations or alterations in the UQCRQ gene can lead to impaired oxidative phosphorylation, resulting in decreased ATP synthesis and increased production of reactive oxygen species, which can further contribute to cell damage and apoptosis. Given its foundational role in bioenergetics and disease processes, studies involving UQCRQ focus on elucidating its structural properties, functional mechanisms, and potential as a therapeutic target. Investigating the reconstitution of UQCRQ and its interactions within the electron transport chain not only deepens our understanding of mitochondrial biology but may also pave the way for developing interventions to mitigate the effects of diseases characterized by mitochondrial dysfunction. Current research harnesses techniques such as cryo-electron microscopy and biophysical assays to explore UQCRQ's role in maintaining mitochondrial integrity and function, emphasizing its importance in both health and disease.
