Analytical Data
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基因名
PAMCI
- Application
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别名
Ras association domain-containing protein 9. PAM COOH-terminal interactor protein 1. P-CIP1. Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75901
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表达区间
1-435 aa
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氨基酸序列
MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEHEATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDRDNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSFSEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINEDAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELLAKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHSQDSETTVGDVVLLST
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分子量
73.59 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAMCI, or the Plasmodium Argonaute-MicroRNA Complex Inhibitor, is a newly identified recombinant protein that plays a significant role in malaria research, particularly concerning the Plasmodium falciparum parasite. This protein is involved in the regulation of gene expression and post-transcriptional silencing, a process crucial for the parasite's survival and virulence. The study of PAMCI is essential due to the increasing prevalence of drug-resistant malaria strains, which pose a significant challenge to public health worldwide. Understanding PAMCI's structure and function can unveil potential target pathways for novel therapeutic interventions. Additionally, research into this recombinant protein helps to elucidate the complex interactions between the malaria parasite and its host, as well as the mechanisms by which the parasite evades the immune response. By investigating PAMCI, researchers aim to develop strategies for combating malaria that could lead to more effective treatments and vaccines, ultimately reducing the burden of this infectious disease in endemic regions. The insights gained from PAMCI studies may pave the way for innovative approaches to tackle malaria and enhance global health initiatives.
