Analytical Data
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Gene name
ARHGAP11A
- Application
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Alternative Names
ARHGAP11A; GAP (1-12); RHG11A; RHGBA; RHGBA_HUMAN; Rho GTPase-activating Protein 11A; Rho-type GTPase-activating Protein 11A
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6P4F7
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Expression Region
1-501aa
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AA Sequence
MWDQRLVRLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEDHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKATLLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAAVVQTLIDYASDIGRVPDFILEKIPAMLGIDGLCATPSLEGFEEGEYETPGEYKRKRRQSVGDFVSGALNKFKPNRTPSITPQEERIAQLSESPVILTPNAKRTLPVDSSHGFSSKKRKSIKHNFNFELLPSNLFNSSSTPVSVHIDTSSEGSSQSSLSPVLIGGNHLITAGVPRRSKRIAGKKVCRVESGKAGCFSPKISHKEKVRRSLRLKFNLGKNGREVNGCSGVNRYESVGWRLANQQSLKNRIESVKTGLLFSPDVDEKLPKKGTFTYYC
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Molecular Weight
81.51 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGAP11A is a member of the Rho GTPase-activating protein family, which plays a crucial role in regulating cellular processes such as actin cytoskeleton dynamics and cell migration. This protein has garnered significant attention due to its unique evolutionary history, being specifically associated with the human lineage and involved in the development of the neocortex—a brain region critical for higher cognitive functions. Research has shown that ARHGAP11A is implicated in promoting neural stem cell proliferation and enhancing the expansion of neural progenitor cells, thereby influencing brain size and complexity. Its ability to facilitate the formation of folding structures in the developing cortex suggests its potential contributions to evolutionary advancements in brain architecture and function. Understanding ARHGAP11A's mechanisms at the molecular level could provide insights into human brain evolution and offer novel perspectives for studying neurodevelopmental disorders. As scientists explore the potential therapeutic applications of ARHGAP11A in neural regeneration and repair, recombinant forms of this protein are being developed and studied for their functional properties, further illuminating the intricate interplay between genetics, brain development, and evolution.
