Analytical Data
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基因名
P18SRP
- Application
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别名
SREK1IP1; P18SRP; SFRS12IP1; Protein SREK1IP1; SFRS12-interacting protein 1; SREK1-interacting protein 1; Splicing regulatory protein of 18 kDa; p18SRP
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N9Q2
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表达区间
1-155 aa
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氨基酸序列
MAVPGCNKDS VRAGCKKCGY PGHLTFECRN FLRVDPKRDI VLDVSSTSSE DSDEENEELN KLQALQEKRI NEEEEKKKEK SKEKIKLKKK RKRSYSSSST EEDTSKQKKQ KYQKKEKKKE KKSKSKKGKH HKKEKKKRKK EKHSSTPNSS EFSRK
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分子量
18.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The P18SRP protein, a key component of the signal recognition particle (SRP) pathway, has garnered attention in recent years due to its crucial role in the co-translational targeting of nascent proteins to the endoplasmic reticulum (ER) in eukaryotic cells. This pathway is essential for the proper functioning of cells, as it ensures that secretory and membrane proteins are accurately synthesized and directed to their appropriate destinations. Research into P18SRP focuses on its structure, functional mechanisms, and interactions with other SRP components, as well as its implications in cellular processes such as protein folding and quality control. Mutations or dysfunctions in the proteins involved in this pathway, including P18SRP, have been linked to various diseases, including neurodegenerative disorders and cancers, highlighting the significance of understanding its biology. Furthermore, studies utilizing advanced techniques such as cryo-electron microscopy and biochemical assays have revealed intricate details of P18SRP’s interactions and confirm its pivotal role in the SRP mechanism. As a result, P18SRP not only serves as a fundamental topic in cellular and molecular biology but also holds potential for therapeutic interventions, making it a subject of increasing interest in biomedical research.
